A possibility for application of new O, N-collectors of hydrazides class in flotation of Ural copper-zinc ores of different types: pyrite with fine dissemination of copper and zinc sulfides, oxidized Cu-Fe-vanadium and mixed (pyrite-copper dis-seminated), is shown. The obtained results are comparable with those achieved with application of potassium butyl xanthate, conventionally used for these purposes. Special features of hydrazide G-18I, that demonstrated the strongest collecting properties, if compared with potassium butyl xanthate, are higher chemical stability and a different sulfur distribution in flotation products.