The way of updating sulpfidydrilic collectors carboxyl by acids and tetraphenylantimony (V) is developed. Efficiency shortchein carboxyl the acids modified dythio by fragments at flotation antimony copper and gold-bearing polymetallic ores in a mix with sulpfidegidril reagents is shown. At application of a combination of reagents it is observed synergism. Stereochemical representations about molecules flotoreagents are considered. The computer technology and chemical programs for visualization of three-dimensional model of a molecule sulpfidydrilic collectors and their complexes with tetraphenylantimony (V) is used: hemispherical Stuart—Brigleba, billstick. Essentially new mechanism of interaction of collectors with sulphide minerals is offered. The opportunity both S-monodentate, and S, S'-bidentate coordination ionic dialkyldithiophosphate reagents — collectors in complexes tetraphenylantimony (V) is established. This circumstance underlies essentially various way of coordination dialkyldithiophosphate (mainly S-monodentate) and dialkyldithiocarbame groups (S, S'-bidentate–xelate ).